Families, including young children, were outside on the summer night when gunfire erupted on the block around 8:45 p.m. on South Bucknell and Oakford streets.
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Home surveillance video captured the scene as the sounds of gunfire could be heard and residents took cover behind parked vehicles.
In the video, one resident can be heard screaming, "Where are the kids?"
The children on the block were not injured in the shootout, police say.
"I thought it was the kids shooting firecrackers, and then I see the cops come. So I came to the window and I seen the boy, they're putting the boy in the cop car - he had got shot, they were taking him to the hospital," said Henrietta Graham of Point Breeze.
Chopper 6 over quadruple shooting in Point Breeze
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Raheem Hargust and Vincent Jackson, both 36 years old, were pronounced dead at the hospital, according to police.
A 25-year-old man and a 28-year-old man were both listed in critical condition.
Police believe at least one of the shooting victims fired a weapon.
"It appears that all four individuals were targeted. Of those four, we know at least one was in possession of a gun - possibly more, however," said Philadelphia Police Inspector D.F. Pace.
"We know that a silver or gray vehicle left the scene. We believe that was involved as well, and contains inside some of the gunmen," Pace added.
More than 30 spent shell casings were found at the scene.
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"Bottom line? Marvin Gaye: 'What's going on? Babies dying, mothers crying.' That's what I think. I'm 65 years old. I watched these kids, I watched them grow up. It's just crazy all over," said Thomas Moore of Point Breeze.
No arrests have been made.
Anyone with information is asked to call police at 215-686-TIPS.
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