It happened around 6 p.m. on the 2000 block of Brill Street in the city's Wissinoming section.
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Police say a 16-year-old boy died at the hospital after being shot.
Two other male victims, a 35-year-old and a 42-year-old, were also injured by gunfire.
The 42-year-old man is listed as critical at Jefferson Torresdale Hospital. The 35-year-old man was placed in stable condition.
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No arrests have been made.
Anyone with information is asked to call police at 215-686-TIPS.
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