It happened on the 2400 block of North 19th Street around 9 p.m.
Police say they found a 14-year-old boy suffering from a gunshot wound to the foot.
Another 14-year-old girl was injured after being cut by glass during the shooting.
Both teens were hospitalized and are listed in stable condition.
Action News was there as police scattered dozens of evidence markers near a cordoned-off area of the block.
Investigators are still searching for the gunman.
Anyone with any information is asked to call police at 215-686-TIPS.