It happened around 7:34 p.m. inside a home on the 1800 block of North 20th Street.
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Police say a 5-year-old girl and a 37-year-old woman were both stabbed multiple times in a first-floor bedroom.
According to police, the 37-year-old suffered multiple stab wounds to her arms and chest. She was taken to Temple University Hospital where she was listed in critical condition.
The 5-year-old girl was found with stab wounds to her chest, abdomen and left arm, police said. She was taken to St. Christopher's Hospital for Children where she was also listed in critical condition.
Police have not said what sparked the stabbing.
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No arrests have been made.
Anyone with information is asked to call police at 215-686-TIPS.