Police say the victim, a 29-year-old man, was stabbed just before 12:30 a.m. Saturday on the 6500 block of North 20th Street.
Investigators say the victim had just arrived home with food from the restaurant where he worked when a verbal altercation took place.
During the argument, the woman took out a knife and stabbed the man in the abdomen.
Police arrived just minutes after they were called.
Medics pronounced the man dead inside the home.
Police arrested the woman and she now faces murder charges.
Investigators say the man's significant other witnessed the crime and is speaking to detectives.
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