It happened before 2 p.m. Saturday in the 2100 block of North 10th and French streets.
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The unidentified woman was shot multiple times and rushed to Temple University Hospital where she was pronounced dead.
A 35-year-old man was shot in the head and also taken to Temple where he later died.
Police say a second male was found inside a car and pronounced dead at the scene.
Two guns were recovered at the scene, police say.
Police are sorting out the details of the triple deadly shooting.
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