Police say the two males got out of a dark-colored minivan at 62nd and Market Streets last Friday just after 1 a.m.
The pair then immediately opened fire.
Police say a 25-year-old victim is in critical condition and an 18-year-old victim is in stable condition.
The minivan was last seen traveling north on 62nd Street towards Arch Street.
Anyone with information is urged to call Philadelphia police.