It happened just before 4:30 p.m. at a laundromat located on the 5600 block of Vine Street in West Philadelphia.
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Police say a 21-year-old man was shot in the head. He was rushed to an area hospital where he later died.
Police originally identified the victim as a 16-year-old boy, but officers now tell Action News the victim is 21 years old.
Chopper 6 was over the scene where officers have a large portion of the strip mall cordoned off.
No arrests have been made.
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Anyone with any information is asked to call police at 215-686-TIPS.
Stay with Action News as we continue to follow this developing story.