The incident was reported at around 8:30 a.m. on the 1300 block of Melvin Road in Phoenixville.
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Neighboring homes were evacuated following some sort of spill, which may have contributed to the fire.
Chopper 6: House fire, hazmat incident in Chester County
Firefighters remained on the scene even after the fire was placed under control.
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The Phoenixville School District issued a shelter-in-place for nearby Phoenixville Middle School and Phoenixville High School, but those orders have since been lifted.
No injuries have been reported.