Officials said it happened sometime around 3:30 a.m at the intersection of 11th and Wharton streets in South Philadelphia, just outside of the 3rd District station.
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The front bumper of the police vehicle was charred and the tires were slashed.
Witnesses told police that someone rode away from the area on a bike.
"A little surprising. It's very quiet here in this neighborhood," said resident Nick Bivens.
A Philadelphia police car was vandalized and set on fire early Wednesday
There were no injuries reported.
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Police are investigating to see if Wednesday morning's incident is connected to the recent series of fires involving police cars across the city approximately one month ago.
Police Commissioner Danielle Outlaw expressed anger after those fires, telling Action News it's a slap in the face to damage vehicles that are used to serve the public.
Arson investigators are working with police on this case.
Anyone with information on this incident is asked to contact the police.