The crash happened just after 4 p.m. Tuesday on I-95 northbound between Rt. 420 and Rt. 291.
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Delaware State Police tell Action News troopers were pursuing a carjacked vehicle.
Troopers said the car was stolen from the parking lot of a treatment facility on the 3300 block of Kirkwood Highway just before 3 p.m. The car was spotted shortly after in Wilmington, Delaware.
Delaware State Police pursued the car on I-95 North, where it crashed in Tinicum Township.
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The female carjacking suspect was taken into custody and transported to an area hospital.
The owner of the car was also taken to an area hospital with non-life threatening injuries, officials say.
The crash caused some delays in the northbound lanes of the highway.