It happened at 6:45 a.m. Thursday on Route 70 at Lakehurst Road.
Video from Chopper 6 HD showed the dump truck lying on its side and a heavily damaged white van next to it.
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RAW VIDEO: Deadly dump truck crash
Police tell Action News one person was pronounced dead at the scene.
Another was taken to Lourdes Emergency Department at Deborah for treatment.
There was no immediate word on that person's condition, or what led to the crash.
Route 70 was shut down in both directions between Pasadena Road and Route 539 as police investigated and crews worked to clear the scene.