Police identified the deceased male Wednesday night as 66-year-old Ronald Clark of Phoenixville.
The crash happened at 6 a.m. Wednesday at South Valley Forge and Potshop roads.
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Police tell Action News a tractor trailer and a pickup truck, driven by Clark, collided at that location.
Rescue crews extricated Clark and the other driver who were trapped in the wreckage.
So far, there's no word on what led to the crash.
Police are investigating.