The crash happened around 12:45 a.m. Saturday in the southbound lanes between the Swarthmore/Media exit and exit 1 McDade Boulevard.
Police say the driver lost control of the vehicle and it rolled over, trapping two people inside.
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Crews worked for more than 30 minutes to rescue the victims, police said.
The driver, a 37-year-old man, died in the crash. The passenger, a 30-year-old woman, is hospitalized at Crozer-Chester Hospital. There is no word on her condition.
The road was closed while police investigated.
Anyone with information is asked to call Pennsylvania State Police at 484-840-1000.