It happened at 4:30 a.m. Monday.
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Police say an SUV collided with a car on 66th Avenue at 18th Street and rolled onto its side.
VIDEO: West Oak Lane crash
A 30-year-old man and a 52-year-old man were taken to an area hospital with stable vital signs.
Police say a third person, who was in the SUV, did not survive.
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66th Avenue was shut down at the scene in both directions.
Police were working to determine what led to the crash.