Police and paramedics responded to a 911 call about the crash at around 1 a.m. along the 700 block of S. Christopher Columbus Blvd.
Police said three young men and three young women were riding in the vehicle.
First responders found the car on its side, crumpled in the front and passenger side with several people trapped, some of them unresponsive.
Action News was told medics got all six of them out of the vehicle and that the three young women sustained the worst injuries.
Police said two of them are 18 years old and that one of them died at the hospital.
Police said she was riding in the back seat.
The other 18-year-old is in critical condition, police said.
The third female, possibly in her early 20s, is also in critical condition, according to investigators.
A witness told police the vehicle was getting off of I-95 South at the Washington Ave. exit and was making the sharp curve onto Christopher Columbus Blvd when it lost control.
"The vehicle struck a curb and according to a witness, the vehicle then went airborne and landed on its passenger side," said Chief Inspector Scott Small.
"This is just a tragic accident only involving one vehicle," Small said.
As for the three males in the car-
Police said the young man who was driving is now stable at the hospital.
They aren't sure about his age just yet, but said he appeared young, possibly a teenager.
There were also two 17-year-old boys in the car who are stable at the hospital, police said.