The collision happened around 9:15 a.m. Friday between the Oaks and Trooper Road exits.
Police say the dump truck driver lost control in the westbound lanes. The truck went off the left side of the roadway, through the retaining guide wire barrier and into the oncoming lanes of 422 East.
The truck struck a silver Ford sedan before overturning and spilling its cargo onto the roadway.
Video from Chopper 6 showed the dump truck on its side. The heavily damaged car could be seen nearby.
The tire tracks were visible in the grassy median.
A fatality was initially reported, but in an update, police say the driver of the sedan was rushed to the hospital. However, the victim is not expected to survive.
The dump truck driver suffered minor injuries.
Parts of the highway were shut down for several hours after the crash, but all lanes have since reopened.
For the latest conditions on area highways, check 6abc.com/Traffic.