It happened at 4 a.m. at South 48th and Walnut streets.
Chopper 6 was over the scene where you can see a heavily damaged SUV in the middle of the roadway and debris scattered all across the street.
One vehicle was struck so hard, it landed on the sidewalk near a house.
One person was pronounced dead at the hospital.
There's no word yet of any other injuries.
The cause of the crash remains under investigation.
Stay with 6abc and 6abc.com as this story develops.