The crash happened around 6:40 a.m. on Thursday near the intersection of Piney Hollow Road and Jackson Road.
Investigators say a Nissan Rogue was traveling east on Piney Hollow Road when it crossed the center of the roadway and entered the westbound lane, colliding with the front end of a Toyota Tundra that was heading west.
The driver of the Nissan, a 41-year-old woman from Vineland, was extracted from the vehicle but was pronounced dead at the scene. Her name has not yet been released.
The driver in the Toyota, a 34-year-old man from Waterford Works, was taken to Cooper Trauma.
Officials said both drivers were not wearing their seatbelts at the time of the crash.
Speed may have been a factor, according to police.