It happened around 8:30 p.m. on the 1600 block of West 5th Street in Wilmington, Delaware.
Detectives say a 16-year-old boy was found shot.
He was rushed to the hospital, where he later died.
The victim's identity has not been released.
No arrests have been made.
The shooting remains under investigation.
Anyone with information is asked to call Delaware Crime Stoppers at 1-800-Tip-3333 or submit a tip online at DelawareCrimeStoppers.com.