Crews were called to the 2600 block of Manton Street around 2:50 a.m. Sunday.
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Arriving firefighters found the first floor engulfed in flames and a woman screaming for help from a second story window.
Crews ran ladders to the window.
They pulled the woman, along with a man and a baby through the window.
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They were taken to the hospital in stable condition.
A dog was found in the basement of the home and was taken to a local veterinarian for care.
Investigators say the fire looks suspicious.