A car plowed into an SUV on East Erie Avenue at M Street.
According to police, the SUV then barreled down the block and slammed into the back of a third car.
A 19-year-old man and a 22-year-old man were taken to the hospital for treatment.
Investigators have not said what vehicle the injured people were traveling in or what caused that first car to lose control.
Police say one driver is being tested for DUI.