It happened around 6:10 p.m. Thursday along the southbound lanes, just north of Cottman Avenue.
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Initial reports are three vehicles collided with two of the three involved catching fire.
Officials say crews experienced the added challenge of getting to the fire due to heavy-volume rush hour traffic.
Once able to apply water on the fire, officials say it took only a matter of minutes to knock down the flames.
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Traffic backlogged several miles as a result of the crash.
The injured were taken to Aria-Torresdale Hospital for care. No word on their conditions at this time.
The roadway has since been reopened.