It happened at 12:40 p.m. Monday in the 2700 block of Route 206.
Authorities tell Action News two vehicles collided, injuring three people.
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One person was said to be trapped in the wreckage.
Images from Chopper 6 HD showed two vehicles, a red SUV and a white sedan, with extensive damage and debris littering the road.
The SUV had left the road and was in some brush adjacent to the highway.
A medical helicopter was standing by a short distance away.
First responders were seen transferring a person on a stretcher from a rescue vehicle into the chopper.
There was no immediate word what led to the crash.
Stay with Action News and 6abc.com for more information as it becomes available.