Firefighters responded to the home in the 100 block of Erial Road around 1 a.m.
When crews arrived, they found heavy fire conditions in all four areas of the home, including the basement with people trapped inside.
Officials say all those residents, including some children, were able to make it out of the home.
They were taken to the hospital for evaluation. There has been no word on their conditions.
Fire officials said it took crews about 40 minutes to get the blaze under control.
There has been no word on what caused the fire.