Animal enforcement executed a search warrant on the home in the 300 block of Spencer Avenue on Tuesday after receiving a tip.
They found 78 Ragdoll cats and kittens living in deplorable and unsanitary conditions, according to officials.
"Some were frightened. Some were sick. All were living in conditions no animal should ever have to endure," PSPCA said in a social media post.
Investigators say they also found feces and trash throughout the home, where the cats were free-roaming inside.
"The air was harsh, but officers spent hours working through those physically demanding conditions to ensure every animal could be found and brought to safety," the post said.
The cats are getting necessary care before being put up for adoption.