It happened just before 12 a.m. near 13th and Walnut streets.
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Officials say a vacant apartment caught fire creating lots of smoke.
The 4-story building has an art gallery on the first floor.
There are also apartments in the building.
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Fortunately, the fire did not spread to any other apartments and no one was injured.
The 2nd Alarmers responded to the scene to provide rehab support.
Investigators have not yet determined a cause.