Officers responded to the 11500 block of East Roosevelt Boulevard at about 10 a.m., according to authorities.
Police said two men approached two people who were inside a Nissan Rogue.
During the robbery, a gun was pointed at a 44-year-old woman inside the vehicle, authorities said.
The suspects took a purse, sneakers, a duffel bag and cash before fleeing the area in a dark Chevrolet Impala, police said.
No additional information was immediately released.
Anyone with information can call or text Philadelphia police at 215-686-TIPS (8477) or submit an anonymous tip online.