Firefighters were called to the store in the 1600 block of South Christopher Columbus Boulevard.
Video obtained by Action News shows flames burning inside one of the aisles of the store.
Customers and employees were evacuated as a precaution. No injuries were reported.
The store is planning to partially reopen sometime Tuesday and is working to fully reopen as soon as possible, Walmart told Action News.
The investigation continues to determine how the fire started.
Anyone with information is asked to call police at 215-686-TIPS.