It happened just after midnight in the southbound lanes of I-95, at mile marker 6.1.
Authorities say a 2026 Peterbilt tractor-trailer was traveling southbound in the right lane and slowed down due to an active construction zone.
A 2016 Hino box truck then struck the rear of the slowed Peterbilt.
Following the crash, the Hino became fully engulfed in flames and the driver was pronounced dead at the scene.
The driver of the Peterbilt was taken to the hospital with non-life-threatening injuries.
The identity of the driver killed has not yet been released.