The shooting happened around 6:30 p.m. in the 3800 block of Fairmount Street.
The 38-year-old male victim was shot in the hip and arm, while the 35-year-old female victim was shot in the arm.
Police believe they know who the gunman is, but so far no arrest has been made.
The suspect fled in a silver sedan.
Anyone with information can call or text Philadelphia police at 215-686-TIPS (8477) or submit an anonymous tip online.