It happened around 11:30 a.m. on the 6600 block of Easton Road (Route 611) in Bedminster Twp.
The circumstances of the crash are unclear.
Video from Chopper 6 showed the charred remains of a vehicle that had caught fire. Another car was nearby with heavy front-end damage.
Meanwhile, firefighters could be seen shoring up the damaged portion of a nearby building that was hit by one of the vehicles.
There was no immediate word on any injuries in this crash.