The accident happened around 3:00 p.m. in Bristol, Bucks County.
Two vehicles were involved in the accident. The view from Chopper 6 showed a light colored pickup truck with substantial front-end damage.
Two people were taken to Aria-Torresdale Hospital. No word on their conditions.
The bridge was shut down for at least an hour as the scene was cleared. It has since reopened.
The cause of the crash is under investigation.