The incident began around 11:30 p.m. near the intersection of G Street and Hunting Park Avenue.
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Police said during a car race someone from a gold-colored Crown Victoria with tinted windows opened fire striking a man in the head.
The man was taken to Temple University Hospital in critical condition.
Officials said while officers were investigating the shooting, police spotted a car that fit the description of the shooter's car and attempted to pull the driver over, but the driver fled leading to a chase.
The driver went north on I-95 with officers in pursuit. According to police, the driver then exited the highway at Cottman Avenue, but then crashed nearby on the 4700 block of Oakmont Street.
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Police said three people ran from the vehicle, with one leaving his shoes behind.
Police are searching for the three suspects.
Anyone with information is asked to contact the police.