It happened around 1:46 p.m. on the 100 block of South 14th Street.
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Three officers with the Catasauqua Police Department responded to the home after an apparent dispute between the man, identified as 27-year-old Ryan Daniel Shirey, and his ex-girlfriend.
According to Pennsylvania State Police, Shirey fled into the basement when officers arrived and retrieved a revolver. The officers followed Shirey and one officer discharged his weapon.
According to WFMZ, Shirey did not comply with the officer's demands to put the weapon down.
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Shirey was shot and pronounced dead at the scene.
No officers were injured in the incident.
The officer who fired his weapon has been placed on administrative leave.