Firefighters responded just before 10 p.m. to the unit block of South 55th Street, where witnesses reported heavy flames coming from the first floor of a home.
Residents on the block said they heard a woman screaming from a second-floor window that her child was trapped inside.
The child was rescued and taken to an area hospital in stable condition.
Officials say a second person who was injured was also hospitalized in stable condition.
The cause of the fire remains under investigation.