Police say the van was traveling at a high rate of speed.
Numerous bystanders tried to help the worker, some performing CPR.
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The worker was taken to Christiana Hospital where he died of his injuries.
The incident occurred around 7:30 p.m. Monday just south of the Route 202 exit at the Brandywine River Bridge.
Police shut down two lanes of I-95 North while they investigated.
The driver of the van stopped at the scene.