It happened just before 11 p.m., closing the southbound between the I-676 east and Market Street exits for several hours. It has since been reopened.
Police say the pedestrian was on the highway for unknown reasons and was hit by a vehicle.
The pedestrian was pronounced dead at the scene.
Anyone who may have witnessed the crash should call police.
No other details have been released.
Get real-time traffic updates at 6abc.com/traffic.