The vehicles involved include a transit bus, two tractor-trailers, a flatbed truck, a box truck and a transit van.
It happened in the outer northbound lanes of the highway just north of Interchange 7 (Route 206) around 11:26 a.m. Tuesday.
State police say the crash remains under investigation.
Authorities say injuries were reported, but they were non-life-threatening.
Video from Chopper 6 showed the bus being hooked up to a tow truck. A damaged van could also be seen.
Sand was being dumped on the roadway for an apparent fluid spill.