It happened before 6:00 a.m. in the eastbound lanes 4 miles past Exit 35 in Lenhartsville.
Police tell Action News the driver of a tractor-trailer lost control and went off the highway and into some trees.
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Another vehicle was involved in the crash as well.
There was no immediate word on the number or extent of any injuries.
All eastbound lanes of I-78 were shut down at Exit 35, where traffic was being detoured off the highway.
Stay with Action News and 6abc.com for more information as it becomes available.