According to investigators, Alexis Woods, 27, was found unresponsive in the front seat of a black Ford Fusion at about 4:10 p.m. after the car hit a guardrail near the Target store.
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Woods, of Philadelphia, was taken to Christiana Hospital where she was later pronounced dead, police said.
Police have charged Shaidiah McNeair, 24, also of Philadelphia, with felony manslaughter and possession of a firearm in the shooting death.
According to police, McNeair was inside of the car but got out before officers arrived. She was arrested at the scene a short time later and is charged with felony manslaughter and possession of a firearm.
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Troopers said while searching the area for possible evidence, they found a white plastic bag along an embankment that contained a handgun.
No other injuries were reported.
Anyone with information is asked to contact police at 302-365-8441.