The crash happened shortly before 5 a.m. on I-78 eastbound in Upper Saucon Township, about a mile past exit 60 for Route 309 South/Quakertown.
Investigators say three people were trying to push a Toyota Sienna out of the right lane of travel when the crash happened.
A tractor-trailer apparently hit the minivan, then struck another tractor-trailer.
One of the people pushing the minivan was killed. That person has not been identified.
The driver of the truck that struck the minivan was also killed. He has been identified as 30-year-old Nicholas Bolotine of East Cocalico Twp., Pa.
A portion of I-78 was closed on Monday morning for the investigation.