It happened around 11:05 a.m. in the northbound lanes, about a mile from the exit to West Chester Pike.
Pennsylvania State Police say the driver was taken to the hospital by medics. That person's condition has not been released.
Video from Chopper 6 showed the heavily damaged Toyota Rav 4 stopped on the highway. Most of the debris from the tree had been moved off to the shoulder.
There were heavy traffic delays in the area as the scene was cleared.
For the latest conditions on area highways, check 6abc.com/Traffic.