The crash happened on Mario Lanza Boulevard around 3:47 p.m.
Police say the black Mitsubishi Outlander was being driven at a high rate of speed in the westbound lanes when the crash occurred.
The driver was taken to the hospital but was pronounced dead shortly after 4:30 p.m.
Video from Chopper 6 showed pieces of the concrete barrier scattered around the scene.
The name of the driver has not been released.
Police say the circumstances of the crash remain under investigation.