The crash happened around 12 p.m. Tuesday near Exit 63 for Sloane Avenue in Hamilton Township.
VIDEO: Dump truck crash on I-295
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It appears the dump truck driver crossed the median and crashed in the southbound lanes.
The view from Chopper 6 showed a damaged guard rail and a trail of manure on the road behind the truck.
A gray SUV with front-end damage and a white SUV with rear-end damage were being towed away from the scene.
There was no immediate word on any injuries.