The blaze broke out around 8:05 am. on the 500 block of Marion Street in Gloucester County.
Officers arrived to heavy smoke and fire coming from the home.
Police have not identified the 73-year-old woman who died.
Officials said an 85-year-old man made it out of the residence before police arrived. He was hospitalized with non-life-threatening injuries.
Four firefighters also sustained minor injuries.
The cause of the fire is still under investigation.