It happened at a health and beauty business near the intersection of Frankford Avenue and Overington Street on the afternoon of March 31.
Police say the suspect entered the store and started hiding items in her clothes.
She was confronted, and police say that's when she sprayed two employees with mace.
She then ran off with multiple stolen items in her possession.
Anyone with information can call or text Philadelphia police at 215-686-TIPS (8477) or submit an anonymous tip online.