It happened just after 2:30 a.m. Saturday in the 1000 block of Baldwin Street.
The victim is identified as 52-year-old Anthony Gorman Sr.
The fire was under control within 20 minutes, but Gorman didn't make it out alive.
Officials say the home had been firebombed twice before.
No word if there is a link to the fatal fire.
The cause of the blaze is under investigation.