It broke out just after 9 p.m. at a barn house along the 100 block of Isabella Road in West Nantmeal Township.
Chopper 6 was over the scene and captured the heavy flames and smoke coming from the area.
WATCH | Chopper 6 flies over fire in West Nantmeal Township, Pa.
Fire crews battle massive blaze burning in Chester County
It is unclear whether anyone was inside when the flames broke out.
It took firefighters roughly three hours to get the fire under control, authorities say.
There is no word yet if any injuries have been reported.
Fire officials are investigating what may have sparked the large fire.