The fire started after 3:30 a.m. Wednesday on the 200 block of North Main Street.
The flames tore through a house subdivided into apartments.
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Firefighters needed extra help battling the flames.
It took about an hour to place the fire under control.
RAW VIDEO: Fire in Sellersville, Pa.
There were no immediate reports of injuries.
The Red Cross has been called to assist the displaced residents.